Emetine and Ipecacuanha: Their Amœbacidal Value in Pathogenic Amœbiasis
نویسنده
چکیده
Ipecacuanha, an ancient Brazilian specific for dysentery, was introduced into Europe by Piso in 1G58. Two years later this drug found its way to India. At first it was little used, but gradually and mainly due to the work of officers of the Indian .Medical Service, it has risen to the position of an amcebacidal specific, more especially when the essential alkaloid emetine is used. Annesley. Twining. Parkes, Mackinnon, Morehead, Fayrer. Maclean and Chevers. laid the foundations of our
منابع مشابه
Amoebic Dysentery and Introduction of Emetine Source Carapichea ipecacuanha into Indian Subcontinent
The South-American herb Carapichea ipecacuanha was feverishly sought after in Europe, since it gained a new popularity as a material useful in treating dysentery, especially after the treatment of Dauphin Louis — the eldest son of Louis XIV of France — by Johann Schweitzer (Jean Helvétius) in Paris in 1686. With the isolation and characterization of emetine from C. ipecacuanha roots by Magendie...
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Callus cultures were induced from leaf segments of Cephaelis ipecacuanha on modified gamborg medium containing 2,4 - dichlorophenoxy acetic acid (2mg/1) Indole acetic acid (1mg/1), kinetin (1mg/1) and sucrose (20g/1). The biogenetic profile for alkaloids was established. The established callus cultures were transferred to modified gamborg medium supplemented with L- DOPA (40 mg/1) and L methion...
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X have already published details of several cases of amoebic dysentery, hepatitis and liver abscess successfully treated by hypodermic injections of soluble salts of emetine (1 and 2) in which the rapidity of recovery from both very acute and very chronic attacks was 1 emavkable. Wrhat is wanted, however, to enable the merits of the new method to be estimated, is a consecutive series of cases o...
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Carapichea ipecacuanha produces various emetine-type alkaloids, known as ipecac alkaloids, which have long been used as expectorants, emetics, and amebicides. In this study, we isolated an O-methyltransferase cDNA from this medicinal plant. The encoded protein (CiOMT1) showed 98% sequence identity to IpeOMT2, which catalyzes the 7'-O-methylation of 7'-O-demethylcephaeline to form cephaeline at ...
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Emetine, a natural alkaloid from Psychotria ipecacuanha, has been used in phytomedicine to induce vomiting, and to treat cough and severe amoebiasis. Certain data suggest the induction of apoptosis by emetine in leukemia cells. Therefore, we examined the suitability of emetine for the sensitisation of leukemia cells to apoptosis induced by cisplatin. In response to emetine, we found a strong re...
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